Optinose Exhalation Delivery System (EDS)
Deposition is different with exhalation
The Optinose Exhalation Delivery System helps deliver medication high and deep in the nasal passages.
Deposition demonstrated through gamma scintigraphy1
Gamma camera image after using an Optinose Exhalation Delivery System with exhalation. The image is from a healthy subject taken 2 minutes after administration with radiolabeled solution and is representative of the overall findings from 211 images and 56 subjects.
The clinical relevance of different deposition patterns has not been established.
Three of the Optinose EDS key features:
Sealing nosepiece
The patented sealing nosepiece is specifically shaped to seal tightly in the nostril, act as a stent in the nasal valve, and allow for the transfer of pressure from the mouth into the nose2
Flexible mouthpiece
The patented flexible mouthpiece enables a broad range of patients to utilize the device while maintaining a seal in the nostril2
Nonremovable
drug-filled vial
The nonremovable drug-filled vial also acts as the actuator, releasing a burst of medication when pressed2
Watch the Optinose EDS in action
How EDS works
- Exhalation elevates the soft palate, creating a seal that separates the nasal cavity from the oropharynx.2
- Air then enters the nostril through the sealing nosepiece, helping expand narrow nasal passages.2
- Medication entrained in the breath is deposited high and deep, flowing around anatomical structures.2
- Air then escapes out the opposite nostril.2
- Exhalation elevates the soft palate, creating a seal that separates the nasal cavity from the oropharynx.2
- Air then enters the nostril through the sealing nosepiece, helping expand narrow nasal passages.2
- Medication entrained in the breath is deposited high and deep, flowing around anatomical structures.2
- Air then escapes out the opposite nostril.2
In a questionnaire of patients in clinical trials, most patients reported that XHANCE was easy to use.3
The clinical trials for XHANCE evaluated over 1500 patients.2
See what makes XHANCE different.