Optinose Exhalation Delivery Systems (EDS):
Deposition is different with exhalation

Optinose Exhalation Delivery Systems help deliver medication high and deep in the nasal passages.

 
 

Deposition demonstrated through gamma scintigraphy1

Gamma scintigraphy showing deposition with an Optinose EDS

Gamma camera image after using an Optinose Exhalation Delivery System with exhalation. The image is from a healthy subject taken 2 minutes after administration with radiolabeled solution and is representative of the overall findings from 211 images and 56 subjects.

The clinical relevance of different deposition patterns has not been established.

3 of the Optinose EDS key features:

Sealing nosepiece

The sealing nosepiece is specifically shaped to seal tightly in the nostril, act as a stent in the nasal valve, and allow for the transfer of pressure from the mouth into the nose1

Flexible mouthpiece

The flexible mouthpiece enables a broad range of patients to utilize the device while maintaining a seal in the nostril1

Nonremovable drug-filled vial

The nonremovable drug-filled vial also acts as the actuator, releasing a burst of medication when pressed1

Device image

x

Sealing nosepiece

The sealing nosepiece is specifically shaped to seal tightly in the nostril, act as a stent in the nasal valve, and allow for the transfer of pressure from the mouth into the nose1

x

Flexible mouthpiece

The flexible mouthpiece enables a broad range of patients to utilize the device while maintaining a seal in the nostril1

x

Nonremovable drug-filled vial

The nonremovable drug-filled vial also acts as the actuator, releasing a burst of medication when pressed1

When using an EDS:

Illustrated image of the a person using an Optinose EDS
  1. Exhalation elevates the soft palate, creating a seal that separates the nasal cavity from the oropharynx.1
  2. Air then enters the nostril through the sealing nosepiece, helping expand narrow nasal passages.1
  3. Medication entrained in the breath is deposited high and deep, flowing around anatomical structures.1
  4. Air then escapes out the opposite nostril.1

Illustrated image of the a person using an Optinose EDS

  1. Exhalation elevates the soft palate, creating a seal that separates the nasal cavity from the oropharynx.1
  2. Air then enters the nostril through the sealing nosepiece, helping expand narrow nasal passages.1
  3. Medication entrained in the breath is deposited high and deep, flowing around anatomical structures.1

Illustrated image of the a person using an Optinose EDS

  1. Air then escapes out the opposite nostril.1

 

>90% of patients in clinical trials considered XHANCE easy to use.1

Learn how XHANCE utilizes an Optinose EDS to treat patients with nasal polyps.
References:
  1. Data on file. OptiNose US, Inc.